Bionanotechnology
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패키지
북카드
작가정보
저자(글) Goodsell, David S.
목차
The Quest for Nanotechnology p. 1 Biotechnology and the Two-Week Revolution p. 3 From Biotechnology to Bionanotechnology p. 4 What is Bionanotechnology? p. 6 Bionanomachines in Action p. 9 The Unfamiliar World of Bionanomachines p. 10 Gravity and inertia are negligible at the nanoscale p. 10 Nanomachines show atomic granularity p. 11 Thermal motion is a significant force at the nanoscale p. 12 Bionanomachines require a water environment p. 13 Modern Biomaterials p. 14 Most natural bionanomachines are composed of protein p. 15 Nucleic acids carry information p. 21 Lipids are used for infrastructure p. 24 Polysaccharides are used in specialized structural roles p. 27 The Legacy of Evolution p. 28 Evolution has placed significant limitations on the properties of natural biomolecules p. 31 Guided Tour of Natural Bionanomachinery p. 32 Biomolecular Design and Biotechnology p. 43 Recombinant DNA Technology p. 45 DNA may be engineered with commercially available enzymes p. 46 Site-directed mutagenesis makes specific changes in the genome p. 52 Fusion proteins combine two functions p. 52 Monoclonal Antibodies p. 54 Biomolecular Structure Determination p. 57 X-ray crystallography provides atomic structures p. 58 NMR spectroscopy may be used to derive atomic structures p. 61 Electron microscopy reveals molecular morphology p. 62 Atomic force microscopy probes the surface of biomolecules p. 64 Molecular Modeling p. 66 Bionanomachines are visualized with computer graphics p. 67 Computer modeling is used to predict biomolecular structure and function p. 68 The protein folding problem p. 69 Docking simulations predict the modes of biomolecular interaction p. 72 New functionalities are developed with computer-assisted molecular design p. 74 Structural Principles of Bionanotechnology p. 75 Natural Bionanomachinery is Designed for a Specific Environment p. 76 A Hierarchical Strategy Allows Construction of Nanomachines p. 77 The Raw Materials: Biomolecular Structure and Stability p. 80 Molecules are composed of atoms linked by covalent bonds p. 80 Dispersion and repulsion forces act at close range p. 84 Hydrogen bonds provide stability and specificity p. 86 Electrostatic interactions are formed between charged atoms p. 87 The hydrophobic effect stabilizes biomolecules in water p. 89 Protein Folding p. 91 Not all protein sequences adopt stable structures p. 93 Globular proteins have a hierarchical structure p. 93 Stable globular structure requires a combination of design strategies p. 95 Chaperones provide the optimal environment for folding p. 98 Rigidity can make proteins more stable at high temperatures p. 100 Many proteins make use of disorder p. 101 Self-Assembly p. 103 Symmetry allows self-assembly of stable complexes with defined size p. 105 Quasisymmetry is used to build assemblies too large for perfect symmetry p. 113 Crowded conditions promote self-assembly p. 115 Self-Organization p. 116 Lipids self-organize into bilayers p. 117 Lipid bilayers are fluid p. 118 Proteins may be designed to self-organize with lipid bilayers p. 119 Molecular Recognition p. 121 Crane principles for molecular recognition p. 122 Atomicity limits the tolerance of combining sites p. 127 Flexibility p. 129 Biomolecules show flexibility at all levels p. 130 Flexibility poses great challenges for the design of bionanomachines p. 134 Functional Principles of Bionanotechnology p. 135 Information-Driven Nanoassembly p. 136 Nucleic acids carry genetic information p. 136 Ribosomes construct proteins p. 140 Information is stored in very compact form p. 142 Energetics p. 145 Chemical energy is transferred by carrier molecules p. 146 Light is captured with specialized small molecules p. 149 Protein pathways transfer single electrons p. 151 Electrical conduction and charge transfer have been observed in DNA p. 155 Electrochemical gradients are created across membranes p. 156 Chemical Transformation p. 158 Enzymes reduce the entropy of a chemical reaction p. 162 Enzymes create environments that stabilize transition states p. 163 Enzymes use chemical tools to perform a reaction p. 164 Regulation p. 167 Protein activity may be regulated through allosteric motions p. 167 Protein action may be regulated by covalent modification p. 171 Biomaterials p. 173 Helical assembly of subunits forms filaments and fibrils p. 174 Microscale infrastructure is built from fibrous components p. 177 Minerals are combined with biomaterials for special applications p. 181 Elastic proteins use disordered chains p. 184 Cells make specific and general adhesives p. 187 Biomolecular Motors p. 189 ATP powers linear motors p. 190 ATP synthase and flagellar motors are rotary motors p. 194 Brownian ratchets rectify random thermal motions p. 201 Traffic Across Membranes p. 203 Potassium channels use a selectivity filter p. 205 ABC transporters use a flip-flop mechanism p. 207 Bacteriorhodopsin uses light to pump protons p. 207 Biomolecular Sensing p. 211 Smell and taste detect specific molecules p. 212 Light is sensed by monitoring light-sensitive motions in retinal p. 213 Mechanosensory receptors sense motion across a membrane p. 213 Bacteria sense chemical gradients by rectification of random motion p. 216 Self-Replication p. 216 Cells are autonomous self-replicators p. 217 The basic design of cells is shaped by the processes of evolution p. 220 Machine-Phase Bionanotechnology p. 221 Muscle sarcomeres p. 221 Nerves p. 224 Bionanotechnology Today p. 227 Basic Capabilities p. 228 Natural proteins may be simplified p. 228 Proteins are being designed from scratch p. 230 Proteins may be constructed with nonnatural amino acids p. 232 Peptide nucleic acids provide a stable alternative to DNA and RNA p. 235 Nanomedicine Today p. 237 Computer-aided drug design has produced effective anti-AIDS drugs p. 238 Immunotoxins are targeted cell killers p. 240 Drugs may be delivered with liposomes p. 241 Artificial blood saves lives p. 243 Gene therapy will correct genetic defects p. 245 General medicine is changing into personalized medicine p. 247 Self-Assembly at Many Scales p. 248 Self-assembling DNA scaffolds have been constructed p. 248 Cyclic peptides form nanotubes p. 250 Fusion proteins self-assemble into extended structures p. 252 Small organic molecules self-assemble into large structures p. 252 Larger objects may be self-assembled p. 254 Harnessing Molecular Motors p. 257 ATP synthase is used as a rotary motor p. 257 Molecular machines have been built of DNA p. 259 DNA Computers p. 261 The first DNA computer solved a traveling salesman problem p. 262 Satisfiability problems are solved by DNA computing p. 264 A Turing machine has been built with DNA p. 265 Molecular Design Using Biological Selection p. 266 Antibodies may be turned into enzymes p. 267 Peptides may be screened with bacteriophage display libraries p. 271 Nucleic acids with novel functions may be selected p. 273 Functional bionanomachines are surprisingly common p. 277 Artificial Life p. 277 Artificial protocells reproduce by budding p. 278 Self-replicating molecules are an elusive goal p. 280 ATP is made with an artificial photosynthetic liposome p. 281 Poliovirus has been created with only a genetic blueprint p. 283 Hybrid Materials p. 285 Nanoscale conductive metal wires may be constructed with DNA p. 285 Patterned aggregates of gold nanoparticles are formed with DNA p. 286 DNA flexes a sensitive mechanical lever p. 287 Researchers are harnessing biomineralization p. 288 Biosensors p. 290 Antibodies are widely used as biosensors p. 291 Biosensors detect glucose levels for management of diabetes p. 292 Engineered nanopores detect specific DNA sequences p. 294 The Future of Bionanotechnology p. 295 A Timetable for Bionanotechnology p. 296 Lessons for Molecular Nanotechnology p. 298 Three Case Studies p. 300 Case study: Nanotube synthase p. 301 Case study: A general nanoscale assembler p. 303 Case study: Nanosurveillance p. 305 Ethical Considerations p. 309 Respect for life p. 309 Potential dangers p. 310 Final thoughts p. 311 Literature p. 313 Sources p. 320 Index p. 323 Table of Contents provided by Rittenhouse. All Rights Reserved.
기본정보
ISBN | 9780471417194 ( 047141719X ) |
---|---|
발행(출시)일자 | 2004년 01월 29일 |
쪽수 | 350쪽 |
크기 |
189 * 240
* 24
mm
/ 766 g
|
총권수 | 1권 |
언어 | 영어 |
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